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TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
LigandBDBM50032547
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1440940 (CHEMBL3375790)
IC50 1.000000±n/a nM
Citation Kawai, KEndo, YAsano, TAmano, SSawada, KUeo, NTakahashi, NSonoda, YNagai, MKamei, NNagata, N Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors. J Med Chem57:9844-54 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Name:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:Enzyme
Mol. Mass.:55514.96
Organism:Homo sapiens (Human)
Description:Q13946
Residue:482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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  Blast E-value cutoff:
BDBM50032547
n/a
NameBDBM50032547
Synonyms:CHEMBL3354181
TypeSmall organic molecule
Emp. Form.C22H27N5O2S
Mol. Mass.425.547
SMILESCCn1c(NC2CCCC2)nc2c(csc2c1=O)-c1ccc(nc1)N1CCOCC1
Structure
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