| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Ligand | BDBM50032636 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1440978 (CHEMBL3375828) |
|---|
| IC50 | 2000±n/a nM |
|---|
| Citation |  Seifert, T; Malo, M; Kokkola, T; Engen, K; Fridén-Saxin, M; Wallén, EA; Lahtela-Kakkonen, M; Jarho, EM; Luthman, K Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells. J Med Chem57:9870-88 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Name: | NAD-dependent protein deacetylase sirtuin-2 |
|---|
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 43172.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 389 |
|---|
| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
|
|
|
|---|
| BDBM50032636 |
|---|
| n/a |
|---|
| Name | BDBM50032636 |
|---|
| Synonyms: | CHEMBL3354206 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14BrClO4 |
|---|
| Mol. Mass. | 361.616 |
|---|
| SMILES | COC(=O)CCCC1CC(=O)c2cc(Cl)cc(Br)c2O1 |
|---|
| Structure | 
|
|---|
Search and Browse
