| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
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| Ligand | BDBM50032647 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440978 (CHEMBL3375828) |
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| IC50 | 28700±n/a nM |
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| Citation |  Seifert, T; Malo, M; Kokkola, T; Engen, K; Fridén-Saxin, M; Wallén, EA; Lahtela-Kakkonen, M; Jarho, EM; Luthman, K Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells. J Med Chem57:9870-88 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-2 |
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| Name: | NAD-dependent protein deacetylase sirtuin-2 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 43172.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 389 |
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| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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| BDBM50032647 |
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| n/a |
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| Name | BDBM50032647 |
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| Synonyms: | CHEMBL3354221 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15BrClNO3 |
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| Mol. Mass. | 420.684 |
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| SMILES | CC(=O)Nc1c(CCc2ccccc2)oc2c(Br)cc(Cl)cc2c1=O |
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| Structure | 
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