| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Suppressor of tumorigenicity 14 protein |
|---|
| Ligand | BDBM50032708 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1441758 (CHEMBL3378881) |
|---|
| Ki | 3.2±n/a nM |
|---|
| Citation |  Duchêne, D; Colombo, E; Désilets, A; Boudreault, PL; Leduc, R; Marsault, E; Najmanovich, R Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2. J Med Chem57:10198-204 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Suppressor of tumorigenicity 14 protein |
|---|
| Name: | Suppressor of tumorigenicity 14 protein |
|---|
| Synonyms: | Epithin | Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein | MT-SP1 | Membrane-type serine protease 1 | PRSS14 | Prostamin | SNC19 | ST14 | ST14_HUMAN | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14 | TADG15 |
|---|
| Type: | Single-pass type II membrane protein |
|---|
| Mol. Mass.: | 94769.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y5Y6 |
|---|
| Residue: | 855 |
|---|
| Sequence: | MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
|
|
|
|---|
| BDBM50032708 |
|---|
| n/a |
|---|
| Name | BDBM50032708 |
|---|
| Synonyms: | CHEMBL3354685 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H48N10O4S |
|---|
| Mol. Mass. | 776.949 |
|---|
| SMILES | CC(C)C[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
