| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 6 |
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| Ligand | BDBM50032698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1442547 (CHEMBL3371671) |
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| Ki | 1.4±n/a nM |
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| Citation |  Duchêne, D; Colombo, E; Désilets, A; Boudreault, PL; Leduc, R; Marsault, E; Najmanovich, R Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2. J Med Chem57:10198-204 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 6 |
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| Name: | Transmembrane protease serine 6 |
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| Synonyms: | Matriptase-2 | TMPRSS6 | TMPS6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90001.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1442547 |
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| Residue: | 811 |
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| Sequence: | MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
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| BDBM50032698 |
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| n/a |
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| Name | BDBM50032698 |
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| Synonyms: | CHEMBL3354676 | N-0130 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H46N12O5S |
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| Mol. Mass. | 722.861 |
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| SMILES | N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r| |
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| Structure | 
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