| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 9 |
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| Ligand | BDBM50032749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1442577 (CHEMBL3372270) |
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| IC50 | 25±n/a nM |
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| Citation |  Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives. J Med Chem57:10013-30 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 9 |
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| Name: | Mitogen-activated protein kinase 9 |
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| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48131.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 424 |
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| Sequence: | MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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| BDBM50032749 |
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| n/a |
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| Name | BDBM50032749 |
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| Synonyms: | CHEMBL3355177 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClN8O2 |
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| Mol. Mass. | 504.971 |
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| SMILES | Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(c1)C1CCNCC1 |
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| Structure | 
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