| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain and PHD finger-containing protein 3 |
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| Ligand | BDBM50032912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1431811 (CHEMBL3385107) |
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| IC50 | <100000±n/a nM |
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| Citation |  Demont, EH; Bamborough, P; Chung, CW; Craggs, PD; Fallon, D; Gordon, LJ; Grandi, P; Hobbs, CI; Hussain, J; Jones, EJ; Le Gall, A; Michon, AM; Mitchell, DJ; Prinjha, RK; Roberts, AD; Sheppard, RJ; Watson, RJ 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett5:1190-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain and PHD finger-containing protein 3 |
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| Name: | Bromodomain and PHD finger-containing protein 3 |
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| Synonyms: | BRPF3 | BRPF3_HUMAN | Bromodomain and PHD finger-containing protein 3 | KIAA1286 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 135743.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108004 |
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| Residue: | 1205 |
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| Sequence: | MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
TSSYL
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| BDBM50032912 |
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| n/a |
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| Name | BDBM50032912 |
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| Synonyms: | CHEMBL1522313 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N4O3 |
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| Mol. Mass. | 394.4668 |
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| SMILES | COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCCCC1 |
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| Structure | 
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