| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50033060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432710 (CHEMBL3389954) |
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| IC50 | 1.4±n/a nM |
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| Citation |  Itadani, S; Takahashi, S; Ima, M; Sekiguchi, T; Fujita, M; Nakayama, Y; Takeuchi, J Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist. ACS Med Chem Lett5:1230-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38565.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
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| Residue: | 337 |
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| Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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| BDBM50033060 |
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| n/a |
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| Name | BDBM50033060 |
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| Synonyms: | CHEMBL3342952 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H30N2O8 |
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| Mol. Mass. | 546.5678 |
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| SMILES | OC(=O)CCC(=O)N1CC(Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc12)C(O)=O |
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| Structure | 
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