| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Ligand | BDBM50033616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1435039 (CHEMBL3387685) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Brand, S; Norcross, NR; Thompson, S; Harrison, JR; Smith, VC; Robinson, DA; Torrie, LS; McElroy, SP; Hallyburton, I; Norval, S; Scullion, P; Stojanovski, L; Simeons, FR; van Aalten, D; Frearson, JA; Brenk, R; Fairlamb, AH; Ferguson, MA; Wyatt, PG; Gilbert, IH; Read, KD Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis. J Med Chem57:9855-69 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase 1 |
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| Name: | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56814.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30419 |
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| Residue: | 496 |
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| Sequence: | MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
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| BDBM50033616 |
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| n/a |
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| Name | BDBM50033616 |
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| Synonyms: | CHEMBL3358119 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30Cl2F2N4O2S |
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| Mol. Mass. | 523.467 |
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| SMILES | Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl |
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| Structure | 
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