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TargetFalcipain 2
LigandBDBM50033626
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1435072 (CHEMBL3388289)
IC50 9.6±n/a nM
Citation Conroy, TGuo, JTElias, NCergol, KMGut, JLegac, JKhatoon, LLiu, YMcGowan, SRosenthal, PJHunt, NHPayne, RJ Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem57:10557-63 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Falcipain 2
Name:Falcipain 2
Synonyms:Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:Enzyme
Mol. Mass.:55912.60
Organism:Plasmodium falciparum
Description:Recombinant falcipain-2.
Residue:484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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  Blast E-value cutoff:
BDBM50033626
n/a
NameBDBM50033626
Synonyms:CHEMBL3358144
TypeSmall organic molecule
Emp. Form.C37H54F3N5O8
Mol. Mass.753.8486
SMILES[O-]C(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1CC(OCc2ccccc2)=CC1=O |r,c:49|
Structure
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