| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50035914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1442780 (CHEMBL3375302) |
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| IC50 | 8.0±n/a nM |
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| Citation |  van Niel, MB; Fauber, BP; Cartwright, M; Gaines, S; Killen, JC; René, O; Ward, SI; de Leon Boenig, G; Deng, Y; Eidenschenk, C; Everett, C; Gancia, E; Ganguli, A; Gobbi, A; Hawkins, J; Johnson, AR; Kiefer, JR; La, H; Lockey, P; Norman, M; Ouyang, W; Qin, A; Wakes, N; Waszkowycz, B; Wong, H A reversed sulfonamide series of selective RORc inverse agonists. Bioorg Med Chem Lett24:5769-76 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50035914 |
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| n/a |
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| Name | BDBM50035914 |
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| Synonyms: | CHEMBL3361057 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29FN2O5S2 |
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| Mol. Mass. | 484.604 |
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| SMILES | CC(C)CN(c1cccc(F)c1)S(=O)(=O)c1ccc(OC2CCN(CC2)S(C)(=O)=O)cc1 |
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| Structure | 
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