| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50380399 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432001 (CHEMBL3388106) |
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| IC50 | 854±n/a nM |
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| Citation |  Blackburn, C; Barrett, C; Brunson, M; Chin, J; England, D; Garcia, K; Gigstad, K; Gould, A; Gutierrez, J; Hoar, K; Rowland, RS; Tsu, C; Ringeling, J; Wager, K; Xu, H Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform. Bioorg Med Chem Lett24:5450-4 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50380399 |
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| n/a |
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| Name | BDBM50380399 |
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| Synonyms: | CHEMBL2018302 | Tubastatin A | US10227295, Compound Tubastatin A | US10456394, Tubastatin A | US11207431, Example D | US8748451, 6 | US9249087, Tubacin | US9751832, Tubastatin A | US9956192, Compound Tubastatin-A |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O2 |
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| Mol. Mass. | 335.3996 |
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| SMILES | CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO |
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| Structure | 
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