| Reaction Details |
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 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
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| Ligand | BDBM50036309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432010 (CHEMBL3388115) |
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| IC50 | 3.2±n/a nM |
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| Citation |  Playa, H; Lewis, TA; Ting, A; Suh, BC; Muņoz, B; Matuza, R; Passer, BJ; Schreiber, SL; Buolamwini, JK Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorg Med Chem Lett24:5801-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Equilibrative nucleoside transporter 1 |
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| Name: | Equilibrative nucleoside transporter 1 |
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| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 50225.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 456 |
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| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
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| BDBM50036309 |
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| n/a |
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| Name | BDBM50036309 |
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| Synonyms: | CHEMBL3353072 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H50N2O10 |
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| Mol. Mass. | 646.7682 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)OCCCCN1CC(C)N(CCCCOC(=O)c2cc(OC)c(OC)c(OC)c2)CC1C |
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| Structure | 
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