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Reaction Details
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TargetHistamine H4 receptor
LigandBDBM22566
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1434446 (CHEMBL3388263)
Ki 5.0±n/a nM
Citation Savall, BMMeduna, SPVenable, JWei, JSmith, RCHack, MDThurmond, RLMcGovern, PEdwards, JP The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands. Bioorg Med Chem Lett24:5489-92 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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  Blast E-value cutoff:
BDBM22566
n/a
NameBDBM22566
Synonyms:5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole | CHEMBL129198 | JNJ 7777120
TypeSmall organic molecule
Emp. Form.C14H16ClN3O
Mol. Mass.277.749
SMILESCN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Structure
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