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TargetGenome polyprotein
LigandBDBM50037446
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1437305 (CHEMBL3384808)
Ki 390±n/a nM
Citation Lampa, AAlogheli, HEhrenberg, AEÅkerblom, ESvensson, RArtursson, PDanielson, UHKarlén, ASandström, A Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles. Bioorg Med Chem22:6595-615 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Genome polyprotein
Name:Genome polyprotein
Synonyms:Nonstructural protein NS3-4A
Type:PROTEIN
Mol. Mass.:71633.49
Organism:Hepatitis C virus
Description:ChEMBL_109716
Residue:674
Sequence:
SPITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVFHGAG
SKTLAGPKGPITQMYTNVDQDLVGWMAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFVPVESMETTMR
SPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAGTDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIICDECHSTDSTTLGI
GTVLDQAETAGARLVVLATATPPGSTVPHPNIEEVALSTTGEIPFYGKAIPIETIKGGRH
LIFCHSKKKCDELAGKLSALGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDS
VIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRGIYRFVTPGERPSGM
FDSSVLCECYDAGCAWYELTPAETTRLRAYLNTPGLPVCQDHLEFWEGVFTGLTIDAHFL
SQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLRLKPTLHGPTPLLYRLGAVQNE
ITLTHPITKIMTCMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGRPAVP
DREVLYEFDEMEEC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50037446
n/a
NameBDBM50037446
Synonyms:CHEMBL3356718
TypeSmall organic molecule
Emp. Form.C41H44N6O8S
Mol. Mass.780.888
SMILESCC(C)(C)[C@@H]1NC(=O)OCC\C=C\c2cc(Oc3ccc(cc3)[C@H](NC1=O)C(=O)Nc1ccccc1C(=O)NS(=O)(=O)CCCC=C)nc(n2)-c1ccccc1 |r,t:11|
Structure
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