| Reaction Details |
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 | Report a problem with these data |
| Target | Nonstructural protein NS3-4A |
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| Ligand | BDBM50037501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1437305 |
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| Ki | 63±n/a nM |
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| Citation |  Lampa A; Alogheli H; Ehrenberg AE; Åkerblom E; Svensson R; Artursson P; Danielson UH; Karlén A; Sandström A Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles. Bioorg Med Chem 22:6595-615 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nonstructural protein NS3-4A |
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| Name: | Nonstructural protein NS3-4A |
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| Synonyms: | Nonstructural protein NS3-4A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71633.49 |
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| Organism: | Hepatitis C virus |
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| Description: | ChEMBL_109716 |
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| Residue: | 674 |
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| Sequence: | SPITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVFHGAG
SKTLAGPKGPITQMYTNVDQDLVGWMAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFVPVESMETTMR
SPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAGTDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIICDECHSTDSTTLGI
GTVLDQAETAGARLVVLATATPPGSTVPHPNIEEVALSTTGEIPFYGKAIPIETIKGGRH
LIFCHSKKKCDELAGKLSALGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDS
VIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRGIYRFVTPGERPSGM
FDSSVLCECYDAGCAWYELTPAETTRLRAYLNTPGLPVCQDHLEFWEGVFTGLTIDAHFL
SQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLRLKPTLHGPTPLLYRLGAVQNE
ITLTHPITKIMTCMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGRPAVP
DREVLYEFDEMEEC
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| BDBM50037501 |
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| n/a |
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| Name | BDBM50037501 |
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| Synonyms: | CHEMBL1170408 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H59N5O9S |
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| Mol. Mass. | 870.064 |
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| SMILES | CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)c1ccc(Oc2cc(nc3cc(OC)ccc23)-c2ccccc2)c(C=C)c1)C(=O)NS(=O)(=O)CCCC=C |r| |
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| Structure | 
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