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TargetKinesin-like protein KIFC1
LigandBDBM50037910
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1438848
IC50 14500±n/a nM
Citation Yang BLamb MLZhang THennessy EJGrewal GSha LZambrowski MBlock MHDowling JESu NWu JDeegan TMikule KWang WKaspera RChuaqui CChen H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem 57:9958-70 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kinesin-like protein KIFC1
Name:Kinesin-like protein KIFC1
Synonyms:HSET | KIFC1 | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET
Type:PROTEIN
Mol. Mass.:73763.89
Organism:Homo sapiens (Human)
Description:ChEMBL_109524
Residue:673
Sequence:
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50037910
n/a
NameBDBM50037910
Synonyms:CHEMBL3358251
TypeSmall organic molecule
Emp. Form.C30H24F3NO4
Mol. Mass.519.5111
SMILESOC(=O)[C@@H](Cc1ccc(cc1)-c1cccc(c1)C(F)(F)F)NC(=O)c1ccccc1OCc1ccccc1 |r|
Structure
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