| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIFC1 |
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| Ligand | BDBM50216502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438848 (CHEMBL3390316) |
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| IC50 | >100000±n/a nM |
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| Citation |  Yang, B; Lamb, ML; Zhang, T; Hennessy, EJ; Grewal, G; Sha, L; Zambrowski, M; Block, MH; Dowling, JE; Su, N; Wu, J; Deegan, T; Mikule, K; Wang, W; Kaspera, R; Chuaqui, C; Chen, H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem57:9958-70 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIFC1 |
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| Name: | Kinesin-like protein KIFC1 |
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| Synonyms: | HSET | HSET | KIFC1 | KIFC1_HUMAN | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73763.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109524 |
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| Residue: | 673 |
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| Sequence: | MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK
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| BDBM50216502 |
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| n/a |
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| Name | BDBM50216502 |
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| Synonyms: | 4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL236789 | monastrol | rac-monastrol |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O3S |
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| Mol. Mass. | 292.353 |
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| SMILES | CCOC(=O)C1C(NC(=S)N=C1C)c1cccc(O)c1 |w:6.13,c:10| |
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| Structure | 
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