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TargetKinesin-like protein KIFC1
LigandBDBM50216502
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1438848
IC50>100000±n/a nM
Citation Yang BLamb MLZhang THennessy EJGrewal GSha LZambrowski MBlock MHDowling JESu NWu JDeegan TMikule KWang WKaspera RChuaqui CChen H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem 57:9958-70 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kinesin-like protein KIFC1
Name:Kinesin-like protein KIFC1
Synonyms:HSET | KIFC1 | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET
Type:PROTEIN
Mol. Mass.:73763.89
Organism:Homo sapiens (Human)
Description:ChEMBL_109524
Residue:673
Sequence:
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50216502
n/a
NameBDBM50216502
Synonyms:4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester | CHEMBL236789 | monastrol | rac-monastrol
TypeSmall organic molecule
Emp. Form.C14H16N2O3S
Mol. Mass.292.353
SMILESCCOC(=O)C1C(NC(=S)N=C1C)c1cccc(O)c1 |w:6.13,c:10|
Structure
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