Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetKinesin-like protein KIFC1
LigandBDBM50037962
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1438848
IC50 2000±n/a nM
Citation Yang BLamb MLZhang THennessy EJGrewal GSha LZambrowski MBlock MHDowling JESu NWu JDeegan TMikule KWang WKaspera RChuaqui CChen H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem 57:9958-70 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kinesin-like protein KIFC1
Name:Kinesin-like protein KIFC1
Synonyms:HSET | KIFC1 | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET
Type:PROTEIN
Mol. Mass.:73763.89
Organism:Homo sapiens (Human)
Description:ChEMBL_109524
Residue:673
Sequence:
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50037962
n/a
NameBDBM50037962
Synonyms:CHEMBL3358275
TypeSmall organic molecule
Emp. Form.C30H34F3N3O4
Mol. Mass.557.6039
SMILESCOCc1cc(ccc1OC)C(=O)N[C@@H](Cc1ccc(cc1)-c1cccc(c1)C(F)(F)F)C(=O)NCCN(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: