Reaction Details |
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Target | Kinesin-like protein KIFC1 |
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Ligand | BDBM50037895 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1438848 (CHEMBL3390316) |
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IC50 | 2100±n/a nM |
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Citation | Yang, B; Lamb, ML; Zhang, T; Hennessy, EJ; Grewal, G; Sha, L; Zambrowski, M; Block, MH; Dowling, JE; Su, N; Wu, J; Deegan, T; Mikule, K; Wang, W; Kaspera, R; Chuaqui, C; Chen, H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem57:9958-70 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kinesin-like protein KIFC1 |
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Name: | Kinesin-like protein KIFC1 |
Synonyms: | HSET | HSET | KIFC1 | KIFC1_HUMAN | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET |
Type: | PROTEIN |
Mol. Mass.: | 73763.89 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109524 |
Residue: | 673 |
Sequence: | MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK
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BDBM50037895 |
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n/a |
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Name | BDBM50037895 |
Synonyms: | CHEMBL3358259 |
Type | Small organic molecule |
Emp. Form. | C31H36F3N3O4 |
Mol. Mass. | 571.6304 |
SMILES | CCOc1cc(OCC)cc(c1)C(=O)NC(Cc1ccc(cc1)-c1cccc(c1)C(F)(F)F)C(=O)NCCN(C)C |
Structure |
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