| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIFC1 |
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| Ligand | BDBM50037967 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1438848 |
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| IC50 | 310±n/a nM |
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| Citation |  Yang B; Lamb ML; Zhang T; Hennessy EJ; Grewal G; Sha L; Zambrowski M; Block MH; Dowling JE; Su N; Wu J; Deegan T; Mikule K; Wang W; Kaspera R; Chuaqui C; Chen H Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. J Med Chem 57:9958-70 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIFC1 |
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| Name: | Kinesin-like protein KIFC1 |
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| Synonyms: | HSET | KIFC1 | KNSL2 | Kinesin-like protein 2 | Kinesin-like protein KIFC1 | Kinesin-related protein HSET |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73763.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109524 |
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| Residue: | 673 |
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| Sequence: | MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK
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| BDBM50037967 |
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| n/a |
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| Name | BDBM50037967 |
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| Synonyms: | CHEMBL3358270 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31F3N4O3S |
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| Mol. Mass. | 560.631 |
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| SMILES | CCCc1cc(sc1C)C(=O)N[C@H](Cc1ccc(nc1)-c1cccc(OC(F)(F)F)c1)C(=O)N[C@@H]1CCNC1 |r| |
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| Structure | 
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