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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50040802 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1444239 (CHEMBL3380178) | ||
| IC50 | <100±n/a nM | ||
| Citation |  Chaudhary, D; Robinson, S; Romero, DL Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem58:96-110 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM50040802 | |||
| n/a | |||
| Name | BDBM50040802 | ||
| Synonyms: | CHEMBL3361258 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H23N5OS | ||
| Mol. Mass. | 369.484 | ||
| SMILES | CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2sc3ccc(cc3c12)C(N)=O |r,wU:3.2,wD:6.9,(14.07,-21.04,;15.39,-21.82,;15.39,-23.35,;16.73,-21.05,;16.74,-19.52,;18.06,-18.75,;19.4,-19.52,;19.4,-21.06,;18.06,-21.83,;20.73,-18.75,;20.73,-17.22,;19.4,-16.45,;19.4,-14.91,;20.72,-14.14,;22.06,-14.9,;23.53,-14.42,;24.44,-15.67,;25.97,-15.82,;26.6,-17.23,;25.69,-18.49,;24.16,-18.32,;23.53,-16.91,;22.06,-16.45,;26.32,-19.89,;27.85,-20.05,;25.42,-21.14,)| | ||
| Structure | 
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