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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50040804 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1444239 (CHEMBL3380178) | ||
| IC50 | <100±n/a nM | ||
| Citation |  Chaudhary, D; Robinson, S; Romero, DL Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem58:96-110 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM50040804 | |||
| n/a | |||
| Name | BDBM50040804 | ||
| Synonyms: | CHEMBL3361256 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22N4S | ||
| Mol. Mass. | 326.459 | ||
| SMILES | CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2sc3ccccc3c12 |r,wU:3.2,wD:6.9,(53.46,-9.22,;54.79,-9.99,;54.79,-11.53,;56.12,-9.23,;56.13,-7.69,;57.46,-6.93,;58.79,-7.7,;58.79,-9.24,;57.46,-10,;60.13,-6.93,;60.12,-5.39,;58.79,-4.62,;58.8,-3.08,;60.12,-2.31,;61.45,-3.08,;62.93,-2.6,;63.84,-3.84,;65.37,-4,;66,-5.4,;65.09,-6.66,;63.55,-6.5,;62.93,-5.09,;61.45,-4.62,)| | ||
| Structure | 
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