Ki Summary

Reaction Details

Report a problem with these data

Target

Neurotensin receptor type 1

Ligand

BDBM50041428

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1446256 (CHEMBL3373066)

>25±n/a nM

Citation

Thomas, JB; Giddings, AM; Olepu, S; Wiethe, RW; Harris, DL; Narayanan, S; Warner, KR; Sarret, P; Longpre, JM; Runyon, SP; Gilmour, BP Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorg Med Chem Lett25:292-6 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neurotensin receptor type 1

Name:

Neurotensin receptor type 1

Synonyms:

NTR1_RAT | Neurotensin receptor 1 | Ntsr | Ntsr1

Type:

PROTEIN

Mol. Mass.:

47070.64

Organism:

Rattus norvegicus

Description:

ChEMBL_1466612

Residue:

424

Sequence:

MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTD
IYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLA
MPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL
MSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQV
NTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRV
QALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYV
SSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATR
ETLY

BDBM50041428

n/a

Name

BDBM50041428

Synonyms:

CHEMBL3356855

Type

Small organic molecule

Emp. Form.

C25H26ClN3O5

Mol. Mass.

483.944

SMILES

COc1cccc(OC)c1-c1nc(nc2ccc(Cl)cc12)C(=O)N[C@@H](C1CCCCC1)C(O)=O |r,wU:24.27,(22.57,-23.73,;23.91,-24.49,;23.91,-26.03,;22.58,-26.8,;22.58,-28.35,;23.92,-29.12,;25.25,-28.35,;26.59,-29.11,;26.59,-30.65,;25.25,-26.8,;26.57,-26.02,;27.91,-26.79,;29.24,-26.02,;29.24,-24.48,;27.88,-23.72,;27.87,-22.19,;26.55,-21.44,;25.22,-22.22,;23.88,-21.46,;25.24,-23.72,;26.57,-24.49,;30.58,-26.78,;30.58,-28.32,;31.91,-26.01,;33.24,-26.77,;34.58,-26,;35.91,-26.77,;37.24,-26.01,;37.24,-24.46,;35.91,-23.69,;34.57,-24.47,;33.25,-28.32,;31.92,-29.09,;34.59,-29.08,)|

Structure