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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neurotensin receptor type 2 | ||
| Ligand | BDBM50041429 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1446253 (CHEMBL3373063) | ||
| EC50 | 14±n/a nM | ||
| Citation |  Thomas, JB; Giddings, AM; Olepu, S; Wiethe, RW; Harris, DL; Narayanan, S; Warner, KR; Sarret, P; Longpre, JM; Runyon, SP; Gilmour, BP Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Bioorg Med Chem Lett25:292-6 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neurotensin receptor type 2 | |||
| Name: | Neurotensin receptor type 2 | ||
| Synonyms: | High-affinity levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2_RAT | Neurotensin receptor 2 | Neurotensin receptor type 2 | Ntr2 | Ntsr2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 46280.50 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_1466615 | ||
| Residue: | 416 | ||
| Sequence: |
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| BDBM50041429 | |||
| n/a | |||
| Name | BDBM50041429 | ||
| Synonyms: | CHEMBL3356854 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24ClN3O5 | ||
| Mol. Mass. | 457.907 | ||
| SMILES | COc1cccc(OC)c1-c1nc(nc2ccc(Cl)cc12)C(=O)N[C@@H](CC(C)C)C(O)=O |r,wU:24.27,(2.86,-22.1,;4.19,-22.87,;4.2,-24.41,;2.87,-25.18,;2.87,-26.72,;4.2,-27.49,;5.54,-26.72,;6.87,-27.49,;6.87,-29.03,;5.53,-25.17,;6.86,-24.4,;8.19,-25.17,;9.52,-24.39,;9.52,-22.85,;8.17,-22.09,;8.16,-20.57,;6.83,-19.81,;5.51,-20.59,;4.17,-19.84,;5.52,-22.09,;6.85,-22.87,;10.86,-25.16,;10.87,-26.7,;12.19,-24.38,;13.53,-25.15,;14.86,-24.38,;16.2,-25.14,;17.53,-24.37,;16.2,-26.68,;13.54,-26.69,;12.2,-27.47,;14.87,-27.46,)| | ||
| Structure | 
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