| Reaction Details |
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 | Report a problem with these data |
| Target | Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
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| Ligand | BDBM50005480 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443869 (CHEMBL3373543) |
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| IC50 | 900±n/a nM |
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| Citation |  Guan, Q; Zuo, D; Jiang, N; Qi, H; Zhai, Y; Bai, Z; Feng, D; Yang, L; Jiang, M; Bao, K; Li, C; Wu, Y; Zhang, W Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues. Bioorg Med Chem Lett25:631-4 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
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| Name: | Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
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| Synonyms: | Tubulin |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1443869 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Similar to alpha-tubulin isoform 1 |
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| Synonyms: | Similar to alpha-tubulin isoform 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 10383.05 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_104716 |
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| Residue: | 99 |
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| Sequence: | CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
|
|
|
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| Component 2 |
| Name: | Similar to alpha-tubulin isoform 1 |
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| Synonyms: | Tubulin |
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| Type: | PROTEIN |
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| Mol. Mass.: | 9422.48 |
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| Organism: | Bos taurus |
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| Description: | EBI_18002 |
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| Residue: | 84 |
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| Sequence: | PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQI
VSSITASLRFDGALTVDLTDVQTS
|
|
|
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| Component 3 |
| Name: | Tubulin beta-2B chain |
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| Synonyms: | TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49932.38 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_211651 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
|
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|
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| BDBM50005480 |
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| n/a |
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| Name | BDBM50005480 |
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| Synonyms: | (-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene | (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | (combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | (combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-methoxy-5-(3,4,5-trimethoxystyryl)phenol | 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol | 5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | 5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol | CHEMBL67 | Combrestatin A-4 | Combrestatin A4 | Combretastastin A-4 | Combretastatin | Combretastatin-A4 | Combretastin A-4 | Z-Combretastatin A-4 | combretastatin A-4, (CSA4) | combretastin A4 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20O5 |
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| Mol. Mass. | 316.3484 |
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| SMILES | COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O |
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| Structure | 
|
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