| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin L1 |
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| Ligand | BDBM50042857 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1444644 |
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| IC50 | 5600±n/a nM |
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| Citation |  Grosche P; Sirockin F; Mac Sweeney A; Ramage P; Erbel P; Melkko S; Bernardi A; Hughes N; Ellis D; Combrink KD; Jarousse N; Altmann E Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg Med Chem Lett 25:438-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin L1 |
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| Name: | Cathepsin (L and K) |
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| Synonyms: | Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50042857 |
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| n/a |
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| Name | BDBM50042857 |
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| Synonyms: | CHEMBL3354494 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20Cl2N4O3 |
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| Mol. Mass. | 483.347 |
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| SMILES | COc1ccc(cc1C(=O)C(C)(C)c1cc(Cl)cc(Cl)c1)C(=O)NCc1ccnc(n1)C#N |
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| Structure | 
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