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TargetCathepsin K
LigandBDBM50042854
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1444643
IC50 95000±n/a nM
Citation Grosche PSirockin FMac Sweeney ARamage PErbel PMelkko SBernardi AHughes NEllis DCombrink KDJarousse NAltmann E Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg Med Chem Lett 25:438-43 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50042854
n/a
NameBDBM50042854
Synonyms:CHEMBL3354497
TypeSmall organic molecule
Emp. Form.C20H27Cl2N3O5S
Mol. Mass.492.416
SMILESCC(C)(C)[C@H](NC(=O)Cc1cc(Cl)cc(Cl)c1)C(=O)NCC(=O)NC\C=C\S(C)(=O)=O |r|
Structure
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