| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
|---|
| Ligand | BDBM50042868 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1444649 (CHEMBL3376647) |
|---|
| IC50 | 1.000000±n/a nM |
|---|
| Citation |  Ishchenko, A; Zhang, L; Le Brazidec, JY; Fan, J; Chong, JH; Hingway, A; Raditsis, A; Singh, L; Elenbaas, B; Hong, VS; Marcotte, D; Silvian, L; Enyedy, I; Chao, J Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg Med Chem Lett25:474-80 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase pim-2 |
|---|
| Name: | Serine/threonine-protein kinase pim-2 |
|---|
| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 34185.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9P1W9 |
|---|
| Residue: | 311 |
|---|
| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
|
|
|
|---|
| BDBM50042868 |
|---|
| n/a |
|---|
| Name | BDBM50042868 |
|---|
| Synonyms: | CHEMBL3354518 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17F2N5O2S |
|---|
| Mol. Mass. | 417.432 |
|---|
| SMILES | Nc1sc(nc1C(=O)Nc1cnccc1O[C@H]1CCNC1)-c1c(F)cccc1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
