Reaction Details | |||
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Target | Serine/threonine-protein kinase Sgk1 | ||
Ligand | BDBM50043019 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1444808 (CHEMBL3379051) | ||
IC50 | 120±n/a nM | ||
Citation | Rosse, G Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase. ACS Med Chem Lett6:19-20 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Sgk1 | |||
Name: | Serine/threonine-protein kinase Sgk1 | ||
Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) | ||
Type: | Other Protein Type | ||
Mol. Mass.: | 48954.40 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. | ||
Residue: | 431 | ||
Sequence: |
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BDBM50043019 | |||
n/a | |||
Name | BDBM50043019 | ||
Synonyms: | CHEMBL3355029 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H21ClFN5O4S | ||
Mol. Mass. | 517.96 | ||
SMILES | O[C@H]1CC[C@@H](CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |r,wU:4.7,wD:1.0,(43,-11.27,;41.45,-11.27,;40.68,-9.93,;39.13,-9.93,;38.37,-11.26,;39.14,-12.6,;40.68,-12.61,;36.83,-11.26,;36.06,-12.6,;34.52,-12.6,;33.75,-13.93,;34.52,-15.27,;36.05,-15.27,;37.07,-16.42,;38.48,-15.8,;38.34,-14.27,;36.83,-13.94,;32.21,-13.93,;31.43,-15.26,;29.89,-15.26,;29.13,-13.92,;27.59,-13.91,;26.81,-15.24,;28.15,-16.01,;26.81,-16.78,;25.27,-15.25,;24.5,-13.91,;22.96,-13.92,;22.18,-12.58,;22.2,-15.25,;22.96,-16.57,;24.5,-16.58,;25.27,-17.91,;29.9,-12.59,;31.44,-12.59,)| | ||
Structure |