| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
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| Ligand | BDBM50043023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1444808 (CHEMBL3379051) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Rosse, G Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase. ACS Med Chem Lett6:19-20 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Sgk1 |
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| Name: | Serine/threonine-protein kinase Sgk1 |
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| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 48954.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
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| Residue: | 431 |
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| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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| BDBM50043023 |
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| n/a |
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| Name | BDBM50043023 |
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| Synonyms: | CHEMBL3355033 | US9718825, Example 308 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23FN6O4S |
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| Mol. Mass. | 498.53 |
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| SMILES | Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2CNCCO2)c2cn[nH]c2n1 |
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| Structure | 
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