| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
|---|
| Ligand | BDBM50043341 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1444814 (CHEMBL3379057) |
|---|
| IC50 | 23000±n/a nM |
|---|
| Citation |  Johnson, CN; Berdini, V; Beke, L; Bonnet, P; Brehmer, D; Coyle, JE; Day, PJ; Frederickson, M; Freyne, EJ; Gilissen, RA; Hamlett, CC; Howard, S; Meerpoel, L; McMenamin, R; Patel, S; Rees, DC; Sharff, A; Sommen, F; Wu, T; Linders, JT Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett6:25-30 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Maternal embryonic leucine zipper kinase |
|---|
| Name: | Maternal embryonic leucine zipper kinase |
|---|
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 74665.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14680 |
|---|
| Residue: | 651 |
|---|
| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
|
|
|
|---|
| BDBM50043341 |
|---|
| n/a |
|---|
| Name | BDBM50043341 |
|---|
| Synonyms: | CHEMBL3355059 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22N4O2 |
|---|
| Mol. Mass. | 362.425 |
|---|
| SMILES | COc1cc(ccc1C(=O)Nc1ccc2CCNCCc2c1)-c1cn[nH]c1 |
|---|
| Structure | 
|
|---|
Search and Browse
