Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMaternal embryonic leucine zipper kinase
LigandBDBM50043342
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1444812 (CHEMBL3379055)
IC50 410±n/a nM
Citation Johnson, CNBerdini, VBeke, LBonnet, PBrehmer, DCoyle, JEDay, PJFrederickson, MFreyne, EJGilissen, RAHamlett, CCHoward, SMeerpoel, LMcMenamin, RPatel, SRees, DCSharff, ASommen, FWu, TLinders, JT Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett6:25-30 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Maternal embryonic leucine zipper kinase
Name:Maternal embryonic leucine zipper kinase
Synonyms:KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:Enzyme
Mol. Mass.:74665.45
Organism:Homo sapiens (Human)
Description:Q14680
Residue:651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50043342
n/a
NameBDBM50043342
Synonyms:CHEMBL3355058
TypeSmall organic molecule
Emp. Form.C20H20N4O
Mol. Mass.332.399
SMILESO=C(Nc1ccc2CCNCCc2c1)c1ccc(cc1)-c1cn[nH]c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: