Reaction Details |
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Target | LIM domain kinase 2 |
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Ligand | BDBM50043416 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1445025 (CHEMBL3372433) |
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IC50 | 39±n/a nM |
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Citation | Goodwin, NC; Cianchetta, G; Burgoon, HA; Healy, J; Mabon, R; Strobel, ED; Allen, J; Wang, S; Hamman, BD; Rawlins, DB Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett6:53-7 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 2 |
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Name: | LIM domain kinase 2 |
Synonyms: | LIMK2 | LIMK2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 72238.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1514398 |
Residue: | 638 |
Sequence: | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
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BDBM50043416 |
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n/a |
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Name | BDBM50043416 |
Synonyms: | CHEMBL3355482 |
Type | Small organic molecule |
Emp. Form. | C21H20N2O3S |
Mol. Mass. | 380.46 |
SMILES | CN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1 |
Structure |
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