Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50043635 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1445052 (CHEMBL3372984) | ||
Ki | >3140±n/a nM | ||
Citation | Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50043635 | |||
n/a | |||
Name | BDBM50043635 | ||
Synonyms: | CHEMBL3355520 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H19ClN6O | ||
Mol. Mass. | 394.857 | ||
SMILES | Clc1ccccc1-n1c2nccn2c2nc(NC3CCCCC3)ncc2c1=O |(33.09,-2.63,;31.76,-3.4,;30.42,-2.64,;29.09,-3.41,;29.09,-4.95,;30.43,-5.72,;31.76,-4.95,;33.1,-5.72,;33.1,-7.27,;31.96,-8.28,;32.58,-9.68,;34.1,-9.53,;34.42,-8.04,;35.75,-7.27,;37.08,-8.05,;38.42,-7.28,;39.75,-8.05,;39.75,-9.6,;38.41,-10.36,;38.4,-11.9,;39.74,-12.67,;41.08,-11.9,;41.08,-10.36,;38.42,-5.73,;37.09,-4.97,;35.76,-5.73,;34.42,-4.95,;34.43,-3.41,)| | ||
Structure |