Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50043639 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1445052 (CHEMBL3372984) | ||
| Ki | 6.6±n/a nM | ||
| Citation |  Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50043639 | |||
| n/a | |||
| Name | BDBM50043639 | ||
| Synonyms: | CHEMBL3355524 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H23ClN8O2 | ||
| Mol. Mass. | 514.966 | ||
| SMILES | CC(=O)N1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2ccnc2n(-c2ccccc2Cl)c3=O)cc1 |(21.77,-35.76,;23.11,-35,;24.44,-35.78,;23.12,-33.46,;21.79,-32.68,;21.79,-31.15,;23.13,-30.39,;24.46,-31.15,;24.46,-32.69,;23.13,-28.85,;21.8,-28.07,;21.8,-26.53,;23.14,-25.77,;23.14,-24.23,;21.81,-23.46,;21.81,-21.91,;20.48,-21.14,;19.15,-21.91,;19.14,-23.45,;20.47,-24.22,;17.81,-24.21,;17.49,-25.7,;15.97,-25.86,;15.36,-24.46,;16.5,-23.44,;16.49,-21.9,;15.16,-21.13,;13.82,-21.9,;12.49,-21.13,;12.49,-19.58,;13.82,-18.81,;15.15,-19.58,;16.48,-18.8,;17.82,-21.13,;17.82,-19.59,;24.47,-26.54,;24.47,-28.07,)| | ||
| Structure | 
| ||