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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50043641 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1445052 (CHEMBL3372984) | ||
| Ki | >3140±n/a nM | ||
| Citation |  Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50043641 | |||
| n/a | |||
| Name | BDBM50043641 | ||
| Synonyms: | CHEMBL3355526 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H23ClN8O | ||
| Mol. Mass. | 486.956 | ||
| SMILES | CN1CCN(CC1)c1ccccc1Nc1ncc2c(n1)n1ccnc1n(-c1ccccc1Cl)c2=O |(55.97,-25.47,;54.64,-26.24,;54.63,-27.78,;53.3,-28.54,;51.97,-27.77,;51.96,-26.23,;53.3,-25.47,;50.64,-28.55,;50.64,-30.08,;49.3,-30.86,;47.97,-30.08,;47.97,-28.54,;49.31,-27.78,;49.31,-26.24,;47.98,-25.47,;47.98,-23.92,;46.65,-23.15,;45.32,-23.91,;45.31,-25.46,;46.64,-26.23,;43.98,-26.22,;43.66,-27.71,;42.14,-27.87,;41.53,-26.47,;42.67,-25.45,;42.66,-23.91,;41.33,-23.14,;39.99,-23.91,;38.65,-23.14,;38.66,-21.59,;39.99,-20.82,;41.32,-21.59,;42.65,-20.81,;43.99,-23.14,;43.99,-21.6,)| | ||
| Structure | 
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