Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Wee1-like protein kinase | ||
Ligand | BDBM50043644 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1445054 (CHEMBL3372986) | ||
EC50 | 2300±n/a nM | ||
Citation | Tong, Y; Torrent, M; Florjancic, AS; Bromberg, KD; Buchanan, FG; Ferguson, DC; Johnson, EF; Lasko, LM; Maag, D; Merta, PJ; Olson, AM; Osterling, DJ; Soni, N; Shoemaker, AR; Penning, TD Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett6:58-62 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
| ||
BDBM50043644 | |||
n/a | |||
Name | BDBM50043644 | ||
Synonyms: | CHEMBL3355529 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H20ClN7O | ||
Mol. Mass. | 457.915 | ||
SMILES | CN1CCCc2ccc(Nc3ncc4c(n3)n3ccnc3n(-c3ccccc3Cl)c4=O)cc12 |(27.6,-44.19,;26.26,-44.96,;26.25,-46.5,;24.92,-47.27,;23.59,-46.49,;23.59,-44.96,;22.26,-44.19,;22.26,-42.65,;23.6,-41.89,;23.6,-40.35,;22.27,-39.57,;22.27,-38.03,;20.94,-37.26,;19.61,-38.02,;19.6,-39.56,;20.93,-40.34,;18.27,-40.33,;17.95,-41.82,;16.43,-41.97,;15.82,-40.58,;16.96,-39.56,;16.95,-38.01,;15.62,-37.25,;14.28,-38.02,;12.95,-37.25,;12.95,-35.7,;14.28,-34.93,;15.61,-35.7,;16.94,-34.92,;18.28,-37.25,;18.28,-35.71,;24.93,-42.65,;24.93,-44.19,)| | ||
Structure |