Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase Sgk3 |
---|
Ligand | BDBM50443628 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1445194 (CHEMBL3375446) |
---|
IC50 | 3100±n/a nM |
---|
Citation | Halland, N; Schmidt, F; Weiss, T; Saas, J; Li, Z; Czech, J; Dreyer, M; Hofmeister, A; Mertsch, K; Dietz, U; Strübing, C; Nazare, M Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett6:73-8 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase Sgk3 |
---|
Name: | Serine/threonine-protein kinase Sgk3 |
Synonyms: | CISK | Cytokine-independent survival kinase | SGK3 | SGK3_HUMAN | SGKL | Serum/glucocorticoid-regulated kinase 3 | Serum/glucocorticoid-regulated kinase-like |
Type: | PROTEIN |
Mol. Mass.: | 57110.99 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1445194 |
Residue: | 496 |
Sequence: | MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
AFVGFSYAPPSEDLFL
|
|
|
BDBM50443628 |
---|
n/a |
---|
Name | BDBM50443628 |
Synonyms: | CHEMBL3092468 | US9174993, 35 | US9221828, 35 |
Type | Small organic molecule |
Emp. Form. | C17H12ClFN6O2S |
Mol. Mass. | 418.833 |
SMILES | Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |
Structure |
|