| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM9920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1456059 (CHEMBL3366443) |
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| IC50 | 171±n/a nM |
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| Citation |  Hu, Q; Yin, L; Hartmann, RW Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. J Med Chem57:5011-22 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM9920 |
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| n/a |
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| Name | BDBM9920 |
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| Synonyms: | (S)Fadrozole | 4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile | 4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl]benzonitrile | CHEMBL31215 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N3 |
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| Mol. Mass. | 223.2731 |
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| SMILES | N#Cc1ccc(cc1)[C@@H]1CCCc2cncn12 |r| |
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| Structure | 
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