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TargetTranscription factor AP-1
LigandBDBM50092879
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1457997
IC50 20±n/a nM
Citation Ye NDing YWild CShen QZhou J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem 57:6930-48 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcription factor AP-1
Name:Transcription factor AP-1
Synonyms:AP1 | Activator protein 1 | JUN | Proto-oncogene c-JUN | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:n/a
Mol. Mass.:35683.24
Organism:Homo sapiens (Human)
Description:P05412
Residue:331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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  Blast E-value cutoff:
BDBM50092879
n/a
NameBDBM50092879
Synonyms:2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide | CHEMBL132495
TypeSmall organic molecule
Emp. Form.C14H8ClF6N3O
Mol. Mass.383.676
SMILESCc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure
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