| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor Jun |
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| Ligand | BDBM50092879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1457997 (CHEMBL3367171) |
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| IC50 | 20±n/a nM |
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| Citation |  Ye, N; Ding, Y; Wild, C; Shen, Q; Zhou, J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem57:6930-48 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor Jun |
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| Name: | Transcription factor Jun |
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| Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
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| Type: | n/a |
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| Mol. Mass.: | 35683.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05412 |
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| Residue: | 331 |
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| Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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| BDBM50092879 |
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| n/a |
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| Name | BDBM50092879 |
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| Synonyms: | 2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide | CHEMBL132495 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8ClF6N3O |
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| Mol. Mass. | 383.676 |
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| SMILES | Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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