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TargetNAD-dependent protein deacetylase sirtuin-1
LigandBDBM50044816
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454387 (CHEMBL3364859)
Ki 24100±n/a nM
Citation Wu, JLi, JXu, MHLiu, D Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole. Bioorg Med Chem Lett24:3050-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD-dependent protein deacetylase sirtuin-1
Name:NAD-dependent protein deacetylase sirtuin-1
Synonyms:NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2
Type:Developmental protein; hydrolase
Mol. Mass.:81626.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:747
Sequence:
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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  Blast E-value cutoff:
BDBM50044816
n/a
NameBDBM50044816
Synonyms:CHEMBL1576457
TypeSmall organic molecule
Emp. Form.C12H7N5OS
Mol. Mass.269.282
SMILESc1coc(c1)-c1nnc2sc(nn12)-c1ccccn1
Structure
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