| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50044948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1457123 (CHEMBL3369467) |
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| IC50 | 21±n/a nM |
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| Citation |  Varnes, JG; Gero, T; Huang, S; Diebold, RB; Ogoe, C; Grover, PT; Su, M; Mukherjee, P; Saeh, JC; MacIntyre, T; Repik, G; Dillman, K; Byth, K; Russell, DJ; Ioannidis, S Towards the next generation of dual Bcl-2/Bcl-xL inhibitors. Bioorg Med Chem Lett24:3026-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50044948 |
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| n/a |
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| Name | BDBM50044948 |
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| Synonyms: | CHEMBL3311494 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H45ClF3N7O6S3 |
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| Mol. Mass. | 944.504 |
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| SMILES | FC(F)(F)S(=O)(=O)c1cc(ccc1N[C@H](CCN1CCOCC1)CSc1ccccc1)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ncc(Cl)cn2)CC1 |r| |
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| Structure | 
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