| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50044922 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1457124 (CHEMBL3369468) |
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| IC50 | 11±n/a nM |
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| Citation |  Varnes, JG; Gero, T; Huang, S; Diebold, RB; Ogoe, C; Grover, PT; Su, M; Mukherjee, P; Saeh, JC; MacIntyre, T; Repik, G; Dillman, K; Byth, K; Russell, DJ; Ioannidis, S Towards the next generation of dual Bcl-2/Bcl-xL inhibitors. Bioorg Med Chem Lett24:3026-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50044922 |
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| n/a |
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| Name | BDBM50044922 |
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| Synonyms: | CHEMBL3311488 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H46ClF3N4O7S4 |
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| Mol. Mass. | 975.578 |
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| SMILES | [O-][S@+](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F)c1ccccc1-c1ccc(Cl)cc1 |r| |
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| Structure | 
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