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TargetBcl-2-like protein 1
LigandBDBM50044953
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1457124 (CHEMBL3369468)
IC50 10.0±n/a nM
Citation Varnes, JGGero, THuang, SDiebold, RBOgoe, CGrover, PTSu, MMukherjee, PSaeh, JCMacIntyre, TRepik, GDillman, KByth, KRussell, DJIoannidis, S Towards the next generation of dual Bcl-2/Bcl-xL inhibitors. Bioorg Med Chem Lett24:3026-33 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50044953
n/a
NameBDBM50044953
Synonyms:CHEMBL3309310
TypeSmall organic molecule
Emp. Form.C43H47ClF3N7O6S3
Mol. Mass.946.52
SMILESCn1ncc(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)c1-c1ccc(Cl)cc1 |r|
Structure
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