Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM50044924 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1457124 (CHEMBL3369468) |
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IC50 | 10.0±n/a nM |
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Citation | Varnes, JG; Gero, T; Huang, S; Diebold, RB; Ogoe, C; Grover, PT; Su, M; Mukherjee, P; Saeh, JC; MacIntyre, T; Repik, G; Dillman, K; Byth, K; Russell, DJ; Ioannidis, S Towards the next generation of dual Bcl-2/Bcl-xL inhibitors. Bioorg Med Chem Lett24:3026-33 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM50044924 |
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n/a |
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Name | BDBM50044924 |
Synonyms: | CHEMBL3309311 |
Type | Small organic molecule |
Emp. Form. | C49H54ClF3N6O8S3 |
Mol. Mass. | 1043.632 |
SMILES | CN(C)C(=O)COc1cccc(c1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F)-c1ccc(Cl)cc1 |r| |
Structure |
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