| Reaction Details |
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 | Report a problem with these data |
| Target | Malate dehydrogenase |
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| Ligand | BDBM50044974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1448377 (CHEMBL3376861) |
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| IC50 | 1300±n/a nM |
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| Citation |  Zinglé, C; Tritsch, D; Grosdemange-Billiard, C; Rohmer, M Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR). Bioorg Med Chem22:3713-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malate dehydrogenase |
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| Name: | Malate dehydrogenase |
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| Synonyms: | MDH_THETH | mdh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35423.44 |
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| Organism: | Thermus thermophilus |
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| Description: | ChEMBL_1448377 |
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| Residue: | 327 |
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| Sequence: | MKAPVRVAVTGAAGQIGYSLLFRIAAGEMLGKDQPVILQLLEIPQAMKALEGVVMELEDC
AFPLLAGLEATDDPKVAFKDADYALLVGAAPRKAGMERRDLLQVNGKIFTEQGRALAEVA
KKDVKVLVVGNPANTNALIAYKNAPGLNPRNFTAMTRLDHNRAKAQLAKKTGTGVDRIRR
MTVWGNHSSTMFPDLFHAEVDGRPALELVDMEWYEKVFIPTVAQRGAAIIQARGASSAAS
AANAAIEHIRDWALGTPEGDWVSMAVPSQGEYGIPEGIVYSFPVTAKDGAYRVVEGLEIN
EFARKRMEITAQELLDEMEQVKALGLI
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| BDBM50044974 |
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| n/a |
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| Name | BDBM50044974 |
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| Synonyms: | CHEMBL3309762 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17ClN2O5S2 |
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| Mol. Mass. | 512.985 |
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| SMILES | Oc1ccc(\C=C2/SC(=S)N(CC(=O)Nc3ccc(Oc4ccc(Cl)cc4)cc3)C2=O)c(O)c1 |
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| Structure | 
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