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TargetAcetylcholine receptor subunit alpha
LigandBDBM50045044
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454471 (CHEMBL3365586)
Ki 944±n/a nM
Citation Yu, LF; Zhang, HK; Caldarone, BJ; Eaton, JB; Lukas, RJ; Kozikowski, AP Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors. J Med Chem57:8204-23 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acetylcholine receptor subunit alpha
Name:Acetylcholine receptor subunit alpha
Synonyms:ACHA_HUMAN | ACHRA | Acetylcholine receptor protein alpha chain | Acetylcholine receptor subunit alpha | CHNRA | CHRNA1 | Cholinergic, Nicotinic Alpha1Beta1DeltaGamma | Cholinergic, Nicotinic Alpha1Beta2 | Nicotinic acetylcholine receptor alpha-1/beta-1 | Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon | Nicotinic acetylcholine receptor alpha2/beta4 | alpha-1 Nicotinic AChR | n-AChR
Type:Ion channel
Mol. Mass.:54542.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:482
Sequence:
MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
QG
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  Blast E-value cutoff:
BDBM50045044
n/a
NameBDBM50045044
Synonyms:CHEMBL3341967
TypeSmall organic molecule
Emp. Form.C10H14ClN3
Mol. Mass.211.691
SMILESClc1cncc(c1)N1CCCNCC1
Structure
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